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Dissociable Neural Routes to Successful Prospective MemoryMark A. McDaniel1 Pamela LaMontagne1 Stefanie M. Beck2 Michael K. Scullin1,3 Todd S. Braver1 1Department of Psychology, Washington University in St. Louis 2Department of Psychology, Technische Universität Dresden 3Department of Neurology, Emory University School of Medicine Mark A. McDaniel, Department of Psychology, Washington University in St. Louis, One Brookings Dr., Campus Box 1125, St. Louis, MO 63130 E-mail: mmcdanie@artsci.wustl.edu Author Contributions M. A. McDaniel and T. S. Braver developed the study concept. M. A. McDaniel, T. S. Braver, and M. K. Scullin were the primary contributors to the study design, with extensive pilot testing to develop a tractable paradigm for fMRI performed by M. K. Scullin. Testing and data collection were performed by P. LaMontagne, and P. LaMontagne and S. M. Beck analyzed and interpreted the data under the supervision of T. S. Braver. M. A. McDaniel, T. S. Braver, P. LaMontagne, and S. M. Beck drafted the manuscript, S. M. Beck developed the Supplemental Material, and M. K. Scullin provided critical revisions. All authors approved the final version of the manuscript for submission. AbstractIdentifying the processes by which people remember to execute an intention at an appropriate moment (prospective memory) remains a fundamental theoretical challenge. According to one account, top-down attentional control is required to maintain activation of the intention, initiate intention retrieval, or support monitoring. A diverging account suggests that bottom-up, spontaneous retrieval can be triggered by cues that have been associated with the intention and that sustained attentional processes are not required. We used a specialized experimental design and functional MRI methods to selectively marshal and identify each process. Results revealed a clear dissociation. One prospective-memory task recruited sustained activity in attentional-control areas, such as the anterior prefrontal cortex; the other engaged purely transient activity in parietal and ventral brain regions associated with attentional capture, target detection, and episodic retrieval. These patterns provide critical evidence that there are two neural routes to prospective memory, with each route emerging under different circumstances.